Diets rich in polyamines like spermidine may extend lifespan. Data is presented from a study with male mice, showing that high polyamine intake increased median lifespan compared to normal polyamine intake. Spermidine levels in humans has been found to decline with age, and lower levels have been observed in individuals with mild cognitive impairment and Alzheimer’s disease.

However on the flip side: extremely high serum spermidine may be a risk for stroke, so there may be a sort of “sweet spot” for optimal functioning, as is discussed in the video.