For example the most successful clubs and most powerful in South American history are Peñarol, Boca Jrs, Nacional, Independiente, River Plate, São Paulo, Gremio, Flamengo, Palmeiras and Santos. What other do you think are great or never heard of this top 10 from the Americans clubs?
Peñarol and Nacional from Uruguay and Boca Juniors from Argentina and Sao Paulo are the only ones from South America who has 3 World Cups of clubs. So to me they are the best ones.
As someone who doesn’t know a lot about South American club football, if you gave me a big list all the major clubs from the continent and asked me to select the 12 most famous:
I would select the 10 listed by the OP plus Fluminense and Corinthians. If you asked for the single most famous I would say Boca Juniors. I have no idea if those answers reflect reality, but they are the most recognizable names to me.
The primary club I follow is Arsenal in the EPL, and we have had multiple players come from Corinthians, so this may affect my answer.